Wade Wilson is a young assassin with a golden heart whom loves having fun. When he meets a beautiful woman named Vanessa, they are a match made in Heaven. Wade is happy, until the doctor brings him the dark news that he has cancer, and is in a terminal phase.
When a recruiter from a secret agency meets with Wade, he agrees to join them. They tell him they'll make him a superhero so he can be cured.
During this experiment, he is being overseen by Ajax and Angel Dust. (Spoiler alert: Ajax's real name is Francis). After weeks without result Wade is put into an airtight tube by Ajax when he makes a joke about his real name. This aggressive treatment works, and Wade becomes immune to everything. Wade is immortal, but his skin is full of lesions.
After a wild ride, together with X-men Colossus and the teenage X-men Negasonic Teenage Warhead, he can finally win back his love Vanessa.